InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apoc1

Summary

InnateDB Gene

IDBG-152061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoc1

Gene Name

apolipoprotein C-I

Synonyms

apo-CI; Apo-CIB; apoC-I; ApoC-IB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040564

Encoded Proteins

IDBP-152063

apolipoprotein C-I

IDBP-264507

apolipoprotein C-I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19689484-19692658

Strand

Reverse strand

Band

Transcripts

ENSMUST00000045035	ENSMUSP00000045571
ENSMUST00000108451	ENSMUSP00000104091

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005504	fatty acid binding
GO:0055102	lipase inhibitor activity

Biological Process

GO:0006641	triglyceride metabolic process
GO:0008203	cholesterol metabolic process
GO:0010900	negative regulation of phosphatidylcholine catabolic process
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034369	plasma lipoprotein particle remodeling
GO:0034382	chylomicron remnant clearance
GO:0034447	very-low-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050995	negative regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001110009 NM_007469

OMIM

CCDS

CCDS39802

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas