InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sox8

Summary

InnateDB Protein

IDBP-152314.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox8

Protein Name

SRY-box containing gene 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025003

InnateDB Gene

IDBG-152312 (Sox8)

Protein Structure

UniProt Annotation

Function

May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}.

Disease Associations

Tissue Specificity

Brain, gut, limb, and testes. Slightly in liver, ovaries, spinal cord, lung and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001755	neural crest cell migration
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007422	peripheral nervous system development
GO:0008584	male gonad development
GO:0010628	positive regulation of gene expression
GO:0010817	regulation of hormone levels
GO:0014015	positive regulation of gliogenesis
GO:0033690	positive regulation of osteoblast proliferation
GO:0035914	skeletal muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045444	fat cell differentiation
GO:0045662	negative regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046533	negative regulation of photoreceptor cell differentiation
GO:0048469	cell maturation
GO:0048484	enteric nervous system development
GO:0048709	oligodendrocyte differentiation
GO:0060009	Sertoli cell development
GO:0060018	astrocyte fate commitment
GO:0060041	retina development in camera-type eye
GO:0060221	retinal rod cell differentiation
GO:0060612	adipose tissue development
GO:0061138	morphogenesis of a branching epithelium
GO:0072034	renal vesicle induction
GO:0072197	ureter morphogenesis
GO:0072289	metanephric nephron tubule formation
GO:0090184	positive regulation of kidney development
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis