Version 5.4
Mus musculus Gene: Sox8
Summary
InnateDB Gene IDBG-152312.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sox8
Gene Name SRY-box containing gene 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024176
Encoded Proteins
IDBP-152314
SRY-box containing gene 8
IDBP-623818
SRY-box containing gene 8
IDBP-623819
SRY-box containing gene 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:25565892-25570686
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000025003 ENSMUSP00000025003
ENSMUST00000174560 ENSMUSP00000133742
ENSMUST00000173447 ENSMUSP00000133403
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001755 neural crest cell migration
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007422 peripheral nervous system development
GO:0008584 male gonad development
GO:0010628 positive regulation of gene expression
GO:0010817 regulation of hormone levels
GO:0014015 positive regulation of gliogenesis
GO:0033690 positive regulation of osteoblast proliferation
GO:0035914 skeletal muscle cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048469 cell maturation
GO:0048484 enteric nervous system development
GO:0048709 oligodendrocyte differentiation
GO:0060009 Sertoli cell development
GO:0060018 astrocyte fate commitment
GO:0060041 retina development in camera-type eye
GO:0060221 retinal rod cell differentiation
GO:0060612 adipose tissue development
GO:0061138 morphogenesis of a branching epithelium
GO:0072034 renal vesicle induction
GO:0072197 ureter morphogenesis
GO:0072289 metanephric nephron tubule formation
GO:0090184 positive regulation of kidney development
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0044798 nuclear transcription factor complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL G3UWS3
UniProt Splice Variant
Entrez Gene 20681
UniGene
RefSeq NM_011447
OMIM
CCDS CCDS28521
HPRD
IMGT
MGI ID MGI:98370
MGI Symbol Sox8
EMBL AC154418
GenPept
RNA Seq Atlas 20681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca