InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chtf18

Summary

InnateDB Protein

IDBP-152449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chtf18

Protein Name

CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043896

InnateDB Gene

IDBG-152447 (Chtf18)

Protein Structure

UniProt Annotation

Function

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Note=Associates with chromatin during S phase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007049	cell cycle
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2384887

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR011704 ATPase, dynein-related, AAA domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF05496
PF07728

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BIW9