InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ywhah

Summary

InnateDB Protein

IDBP-152572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ywhah

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019109

InnateDB Gene

IDBG-152570 (Ywhah)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0035259	glucocorticoid receptor binding
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0006713	glucocorticoid catabolic process
GO:0006886	intracellular protein transport
GO:0007010	cytoskeleton organization
GO:0007088	regulation of mitosis
GO:0021762	substantia nigra development
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050774	negative regulation of dendrite morphogenesis
GO:0086010	membrane depolarization during action potential
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0030659	cytoplasmic vesicle membrane
GO:0070062	extracellular vesicular exosome