Version 5.4
Mus musculus Protein: Acap2
Summary
InnateDB Protein IDBP-152702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acap2
Protein Name ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms 4832442G16; 9530039J15Rik; Centb2; CNT-B2; mKIAA0041;
Species Mus musculus
Ensembl Protein ENSMUSP00000061501
InnateDB Gene IDBG-152700 (Acap2)
Protein Structure
UniProt Annotation
Function GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). {ECO:0000250UniProtKB:Q15057}.
Subcellular Localization Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0032312 regulation of ARF GTPase activity
GO:0036010 protein localization to endosome
GO:0043547 positive regulation of GTPase activity
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0010008 endosome membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1925868
InterPro IPR001164 Arf GTPase activating protein
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF01412
PF00169
PF00023
PF13606
PF11929
PF12796
PRINTS PR00405
PR01415
PIRSF
SMART SM00105
SM00233
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZQK5
PhosphoSite PhosphoSite-Q6ZQK5
TrEMBL D4AFX6
UniProt Splice Variant
Entrez Gene 78618
UniGene Mm.407403
RefSeq NP_084414
MGI ID
MGI Symbol Acap2
OMIM
CCDS CCDS49823
HPRD
IMGT
EMBL AB490692 AK020591 AK129041 AK147319 BC046455
GenPept AAH46455 BAB32141 BAC97851 BAE27843 BAI82352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca