InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lims1

Summary

InnateDB Protein

IDBP-152977.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lims1

Protein Name

LIM and senescent cell antigen-like domains 1

Synonyms

2310016J22Rik; 4921524A02Rik; AI507642; AU021743; AW551584; C430041B13Rik; Lims1l; PINCH; PINCH1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020078

InnateDB Gene

IDBG-152975 (Lims1)

Protein Structure

UniProt Annotation

Function

Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0016337	single organismal cell-cell adhesion
GO:0043009	chordate embryonic development
GO:0043066	negative regulation of apoptotic process
GO:0045216	cell-cell junction organization
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051291	protein heterooligomerization
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000346	negative regulation of hepatocyte proliferation
GO:2001046	positive regulation of integrin-mediated signaling pathway