InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lims1

Summary

InnateDB Gene

IDBG-152975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lims1

Gene Name

LIM and senescent cell antigen-like domains 1

Synonyms

2310016J22Rik; 4921524A02Rik; AI507642; AU021743; AW551584; C430041B13Rik; Lims1l; PINCH; PINCH1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019920

Encoded Proteins

IDBP-152977

LIM and senescent cell antigen-like domains 1

IDBP-152979

LIM and senescent cell antigen-like domains 1

IDBP-270820

LIM and senescent cell antigen-like domains 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169756:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:58323466-58424691

Strand

Forward strand

Band

Transcripts

ENSMUST00000020078	ENSMUSP00000020078
ENSMUST00000020077	ENSMUSP00000020077
ENSMUST00000105468	ENSMUSP00000101108
ENSMUST00000124312
ENSMUST00000148799

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007163	establishment or maintenance of cell polarity
GO:0016337	single organismal cell-cell adhesion
GO:0043009	chordate embryonic development
GO:0043066	negative regulation of apoptotic process
GO:0045216	cell-cell junction organization
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051291	protein heterooligomerization
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000346	negative regulation of hepatocyte proliferation
GO:2001046	positive regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000169756

View Gene Order

ENSBTAG00000010971

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20580

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway

REACT_20649

Cell-extracellular matrix interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

KEGG

INOH

PID NCI

ilk_pathway

Integrin-linked kinase signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.413157

RefSeq

NM_001193303 NM_026148 NM_201242 XM_006513069 XM_006513073

OMIM

CCDS

CCDS23860 CCDS56703

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas