InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ranbp2

Summary

InnateDB Protein

IDBP-153068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ranbp2

Protein Name

RAN binding protein 2

Synonyms

A430087B05Rik; AI256741; NUP358;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003310

InnateDB Gene

IDBG-153066 (Ranbp2)

Protein Structure

UniProt Annotation

Function

E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0015031	protein transport
GO:0016925	protein sumoylation
GO:0033132	negative regulation of glucokinase activity
GO:0046907	intracellular transport
GO:0051028	mRNA transport
GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis

Cellular Component

GO:0005739	mitochondrion
GO:0031965	nuclear membrane
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket

Protein Structure and Domains

PDB ID

MGI:894323

InterPro

IPR000156 Ran binding domain
IPR001440 Tetratricopeptide TPR1
IPR001876 Zinc finger, RanBP2-type
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
IPR022011 Nup358/RanBP2 E3 ligase domain
IPR029000 Cyclophilin-like domain

PFAM