Version 5.4
Mus musculus Gene: Ranbp2
Summary
InnateDB Gene IDBG-153066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ranbp2
Gene Name RAN binding protein 2
Synonyms A430087B05Rik; AI256741; NUP358
Species Mus musculus
Ensembl Gene ENSMUSG00000003226
Encoded Proteins
IDBP-153068
RAN binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153201:
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:58446852-58494155
Strand Forward strand
Band B4
Transcripts
ENSMUST00000003310 ENSMUSP00000003310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 79 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0015031 protein transport
GO:0016925 protein sumoylation
GO:0033132 negative regulation of glucokinase activity
GO:0046907 intracellular transport
GO:0051028 mRNA transport
GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0031965 nuclear membrane
GO:0042405 nuclear inclusion body
GO:0044615 nuclear pore nuclear basket
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153201
View Gene Order
ENSBTAG00000000152
Not yet available
Pathways
NETPATH
REACTOME
REACT_196648
Nuclear Envelope Breakdown pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_196650
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_204192
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_241408
M Phase pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_253543
Glucose transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_240125
Hexose transport pathway
REACT_203949
Glycogen storage diseases pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_250557
Mitotic Prophase pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_202512
Mitotic Anaphase pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_6804
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_212
Glucose transport pathway
REACT_9441
Hexose transport pathway
REACT_9395
Nuclear import of Rev protein pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_6190
Rev-mediated nuclear export of HIV RNA pathway
REACT_6354
Viral Messenger RNA Synthesis pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6167
Influenza Infection pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_25229
Interferon Signaling pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_1275
Mitotic Anaphase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6145
Influenza Life Cycle pathway
REACT_111217
Metabolism pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_6916
Interactions of Rev with host cellular proteins pathway
REACT_71
Gene Expression pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
hdac_classii_pathway
Signaling events mediated by HDAC Class II
ranbp2pathway
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt Q9ERU9
TrEMBL
UniProt Splice Variant
Entrez Gene 19386
UniGene Mm.431695 Mm.485644
RefSeq NM_011240
OMIM
CCDS CCDS23861
HPRD
IMGT
MGI ID MGI:894323
MGI Symbol Ranbp2
EMBL AC158593 AF279458 AK041932 X87337
GenPept AAG17403 BAC31101 CAA60778
RNA Seq Atlas 19386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca