InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MKNK2

Summary

InnateDB Protein

IDBP-15320.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MKNK2

Protein Name

MAP kinase interacting serine/threonine kinase 2

Synonyms

GPRK7; MNK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000309485

InnateDB Gene

IDBG-15316 (MKNK2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269PubMed:11154262, ECO:0000269PubMed:11463832, ECO:0000269PubMed:12897141, ECO:0000269PubMed:16111636, ECO:0000269PubMed:17965020, ECO:0000269PubMed:18299328, ECO:0000269PubMed:20823271, ECO:0000269PubMed:20927323, ECO:0000269PubMed:21149447}.

Subcellular Localization

Isoform 2: Nucleus, PML body.Isoform 1: Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. {ECO:0000269PubMed:11013076}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0046872	metal ion binding

Biological Process

GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0007166	cell surface receptor signaling pathway
GO:0009103	lipopolysaccharide biosynthetic process
GO:0030097	hemopoiesis
GO:0035556	intracellular signal transduction
GO:0071243	cellular response to arsenic-containing substance

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt