Version 5.4
Mus musculus Protein: Slbp
Summary
InnateDB Protein IDBP-153284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slbp
Protein Name stem-loop binding protein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062930
InnateDB Gene IDBG-153280 (Slbp)
Protein Structure
UniProt Annotation
Function RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs. {ECO:0000250, ECO:0000269PubMed:18036581, ECO:0000269PubMed:19470752}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18036581}. Nucleus {ECO:0000269PubMed:18036581}. Note=Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor (By similarity). Polyribosome-associated. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in growing primary but not non-growing oocytes, within the primordial follicles. Also detected in fully-grown oocytes in antral follicles (at protein level). {ECO:0000269PubMed:18036581}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0071207 histone pre-mRNA stem-loop binding
Biological Process
GO:0006398 histone mRNA 3'-end processing
GO:0033260 nuclear cell cycle DNA replication
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
GO:0071204 histone pre-mRNA 3'end processing complex
Protein Structure and Domains
PDB ID MGI:108402
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97440
PhosphoSite PhosphoSite-P97440
TrEMBL Q3U4T7
UniProt Splice Variant
Entrez Gene 20492
UniGene Mm.453316
RefSeq NP_033219
MGI ID
MGI Symbol Slbp
OMIM
CCDS CCDS19205
HPRD
IMGT
EMBL AC132233 AC162898 AK154053 CH466524 U75680
GenPept AAC53530 BAE32343 EDL37425

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca