Version 5.4
Mus musculus Gene: Slbp
Summary
InnateDB Gene IDBG-153280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slbp
Gene Name stem-loop binding protein
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000004642
Encoded Proteins
IDBP-153282
stem-loop binding protein
IDBP-153284
stem-loop binding protein
IDBP-153286
stem-loop binding protein
IDBP-542570
stem-loop binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163950:
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:33634952-33652574
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000075670 ENSMUSP00000075093
ENSMUST00000057551 ENSMUSP00000062930
ENSMUST00000101354 ENSMUSP00000098906
ENSMUST00000146889
ENSMUST00000143003
ENSMUST00000139518
ENSMUST00000148153
ENSMUST00000151081 ENSMUSP00000121978
ENSMUST00000143029
ENSMUST00000126581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0071207 histone pre-mRNA stem-loop binding
Biological Process
GO:0006398 histone mRNA 3'-end processing
GO:0033260 nuclear cell cycle DNA replication
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
GO:0071204 histone pre-mRNA 3'end processing complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163950
View Gene Order
ENSBTAG00000001328
Not yet available
Pathways
NETPATH
REACTOME
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_248407
Processing of Capped Intronless Pre-mRNA pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_235695
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_250734
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_239127
Transport of the SLBP Dependant Mature mRNA pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1364
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs pathway
REACT_405
Transport of the SLBP Dependant Mature mRNA pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_338
Transport of Mature mRNAs Derived from Intronless Transcripts pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z1S0 Q3V2L1
UniProt Splice Variant
Entrez Gene 20492
UniGene Mm.4172 Mm.423418 Mm.453316
RefSeq NM_001289724 NM_009193
OMIM
CCDS CCDS19205
HPRD
IMGT
MGI ID MGI:108402
MGI Symbol Slbp
EMBL AC132233 AC162898 AK131729
GenPept BAE20786
RNA Seq Atlas 20492

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca