InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn3b

Summary

InnateDB Protein

IDBP-153331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn3b

Protein Name

sodium channel, voltage-gated, type III, beta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051627

InnateDB Gene

IDBG-153329 (Scn3b)

Protein Structure

UniProt Annotation

Function

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0006814	sodium ion transport
GO:0007399	nervous system development
GO:0010460	positive regulation of heart rate
GO:0010765	positive regulation of sodium ion transport
GO:0019233	sensory perception of pain
GO:0035725	sodium ion transmembrane transport
GO:0051899	membrane depolarization
GO:0060048	cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0072659	protein localization to plasma membrane
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086010	membrane depolarization during action potential
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086070	SA node cell to atrial cardiac muscle cell communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

MGI:1918882

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BHK2