InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scn3b

Summary

InnateDB Gene

IDBG-153329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn3b

Gene Name

sodium channel, voltage-gated, type III, beta

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049281

Encoded Proteins

IDBP-153331

sodium channel, voltage-gated, type III, beta

IDBP-250688

sodium channel, voltage-gated, type III, beta

IDBP-625184

sodium channel, voltage-gated, type III, beta

IDBP-741840

IDBP-742363

IDBP-742407

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166257:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:40269216-40291618

Strand

Forward strand

Band

A5.1

Transcripts

ENSMUST00000049941	ENSMUSP00000051627
ENSMUST00000114956	ENSMUSP00000110606
ENSMUST00000171835	ENSMUSP00000132933
ENSMUST00000176169
ENSMUST00000175873
ENSMUST00000175949	ENSMUSP00000134820
ENSMUST00000176634
ENSMUST00000176185	ENSMUSP00000135096
ENSMUST00000176547	ENSMUSP00000135470

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0006814	sodium ion transport
GO:0007399	nervous system development
GO:0010460	positive regulation of heart rate
GO:0010765	positive regulation of sodium ion transport
GO:0019233	sensory perception of pain
GO:0035725	sodium ion transmembrane transport
GO:0051899	membrane depolarization
GO:0060048	cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0072659	protein localization to plasma membrane
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086010	membrane depolarization during action potential
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086070	SA node cell to atrial cardiac muscle cell communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000166257

View Gene Order

ENSBTAG00000016768

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.290083 Mm.409052

RefSeq

NM_001083917 NM_001286614 NM_153522 NM_178227

OMIM

CCDS

CCDS23080 CCDS72214

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas