InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cplx2

Summary

InnateDB Protein

IDBP-153420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cplx2

Protein Name

complexin 2

Synonyms

921-L; AI413745; AW492120;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026985

InnateDB Gene

IDBG-153418 (Cplx2)

Protein Structure

UniProt Annotation

Function

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain. {ECO:0000269PubMed:11163241, ECO:0000269PubMed:12915444, ECO:0000269PubMed:20346398}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:7635198}. Note=Enriched at synaptic-releasing sites in mature neurons.

Disease Associations

Tissue Specificity

Nervous system. Expressed predominantly in brain, where it is present in many regions, including hippocampus and cerebellum. In the retina, present at conventional amacrine cell synapses (at protein level). {ECO:0000269PubMed:15911881, ECO:0000269PubMed:7635198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0017075	syntaxin-1 binding
GO:0019905	syntaxin binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0007399	nervous system development
GO:0016079	synaptic vesicle exocytosis
GO:0030154	cell differentiation
GO:0031915	positive regulation of synaptic plasticity
GO:0043303	mast cell degranulation

Cellular Component

GO:0005829	cytosol
GO:0030425	dendrite
GO:0031201	SNARE complex
GO:0042629	mast cell granule
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex