Version 5.4
Mus musculus Gene: Cplx2
Summary
InnateDB Gene IDBG-153418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cplx2
Gene Name complexin 2
Synonyms 921-L; AI413745; AW492120
Species Mus musculus
Ensembl Gene ENSMUSG00000025867
Encoded Proteins
IDBP-153420
complexin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145920:
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:54371349-54383917
Strand Forward strand
Band B1
Transcripts
ENSMUST00000026985 ENSMUSP00000026985
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0007399 nervous system development
GO:0016079 synaptic vesicle exocytosis
GO:0030154 cell differentiation
GO:0031915 positive regulation of synaptic plasticity
GO:0043303 mast cell degranulation
Cellular Component
GO:0005829 cytosol
GO:0030425 dendrite
GO:0031201 SNARE complex
GO:0042629 mast cell granule
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145920
View Gene Order
ENSBTAG00000013741
Not yet available
Cross-References
SwissProt P84086
TrEMBL
UniProt Splice Variant
Entrez Gene 12890
UniGene Mm.268902 Mm.471163
RefSeq NM_009946
OMIM
CCDS CCDS36667
HPRD
IMGT
MGI ID MGI:104726
MGI Symbol Cplx2
EMBL BN000501 BN000502 D38613 U35101
GenPept AAC52272 BAA07604 CAG26661 CAG26662
RNA Seq Atlas 12890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca