Version 5.4
Mus musculus Protein: Pigz
Summary
InnateDB Protein IDBP-153429.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigz
Protein Name phosphatidylinositol glycan anchor biosynthesis, class Z
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000057509
InnateDB Gene IDBG-153427 (Pigz)
Protein Structure
UniProt Annotation
Function Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000026 alpha-1,2-mannosyltransferase activity
GO:0000030 mannosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0097502 mannosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2443822
InterPro IPR005599 GPI mannosyltransferase
PFAM PF03901
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BTP0
PhosphoSite PhosphoSite-Q8BTP0
TrEMBL
UniProt Splice Variant
Entrez Gene 239827
UniGene Mm.446793
RefSeq NP_766410
MGI ID
MGI Symbol Pigz
OMIM
CCDS CCDS28109
HPRD
IMGT
EMBL AK089183 BC117748
GenPept AAI17749 BAC40783

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca