InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rhot2

Summary

InnateDB Protein

IDBP-153546.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhot2

Protein Name

ras homolog gene family, member T2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044639

InnateDB Gene

IDBG-153544 (Rhot2)

Protein Structure

UniProt Annotation

Function

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:15218247}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0019725	cellular homeostasis
GO:0047497	mitochondrion transport along microtubule
GO:0097345	mitochondrial outer membrane permeabilization

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0031307	integral component of mitochondrial outer membrane

Protein Structure and Domains

PDB ID

MGI:2384892

InterPro

IPR001806 Small GTPase superfamily
IPR002048 EF-hand domain
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013566 EF hand associated, type-1
IPR013567 EF hand associated, type-2
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR021181 Small GTPase superfamily, mitochondrial Rho
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM