Version 5.4
Mus musculus Gene: Rhot2
Summary
InnateDB Gene IDBG-153544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhot2
Gene Name ras homolog gene family, member T2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025733
Encoded Proteins
IDBP-153546
ras homolog gene family, member T2
IDBP-715144
IDBP-715174
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140983:
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:25838457-25844851
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000043897 ENSMUSP00000044639
ENSMUST00000177122
ENSMUST00000176247
ENSMUST00000177470
ENSMUST00000176882
ENSMUST00000176604
ENSMUST00000176522
ENSMUST00000176602
ENSMUST00000176709 ENSMUSP00000135436
ENSMUST00000177062
ENSMUST00000176583
ENSMUST00000175869
ENSMUST00000176591 ENSMUSP00000135611
ENSMUST00000177315
ENSMUST00000177347
ENSMUST00000175790
ENSMUST00000176857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0019725 cellular homeostasis
GO:0047497 mitochondrion transport along microtubule
GO:0097345 mitochondrial outer membrane permeabilization
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140983
View Gene Order
ENSBTAG00000004551
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.408765 Mm.490420
RefSeq NM_145999
OMIM
CCDS CCDS37505
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca