InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glrb

Summary

InnateDB Protein

IDBP-153722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glrb

Protein Name

glycine receptor, beta subunit

Synonyms

AI853901; Glyrb; spa; spastic;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029654

InnateDB Gene

IDBG-153720 (Glrb)

Protein Structure

UniProt Annotation

Function

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Note=Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability.

Tissue Specificity

High levels of expression in cortex, hippocampus, thalamus and cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016594	glycine binding
GO:0016933	extracellular-glycine-gated ion channel activity
GO:0016934	extracellular-glycine-gated chloride channel activity

Biological Process

GO:0001964	startle response
GO:0006810	transport
GO:0006811	ion transport
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007340	acrosome reaction
GO:0007399	nervous system development
GO:0007601	visual perception
GO:0007628	adult walking behavior
GO:0034220	ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0050905	neuromuscular process
GO:0051291	protein heterooligomerization
GO:0060012	synaptic transmission, glycinergic
GO:0060013	righting reflex
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:95751

InterPro

IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008060 Glycine receptor beta

PFAM

PF02932
PF02931

PRINTS

PR00253
PR00252
PR01677

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48168