Version 5.4
Mus musculus Gene: Glrb
Summary
InnateDB Gene IDBG-153720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glrb
Gene Name glycine receptor, beta subunit
Synonyms AI853901; Glyrb; spa; spastic
Species Mus musculus
Ensembl Gene ENSMUSG00000028020
Encoded Proteins
IDBP-153722
glycine receptor, beta subunit
IDBP-266020
glycine receptor, beta subunit
IDBP-542898
glycine receptor, beta subunit
IDBP-542899
glycine receptor, beta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109738:
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:80843599-80913660
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000029654 ENSMUSP00000029654
ENSMUST00000107743 ENSMUSP00000103372
ENSMUST00000135043 ENSMUSP00000116604
ENSMUST00000132330 ENSMUSP00000115014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016594 glycine binding
GO:0016933 extracellular-glycine-gated ion channel activity
GO:0016934 extracellular-glycine-gated chloride channel activity
Biological Process
GO:0001964 startle response
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
GO:0007340 acrosome reaction
GO:0007399 nervous system development
GO:0007601 visual perception
GO:0007628 adult walking behavior
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050905 neuromuscular process
GO:0051291 protein heterooligomerization
GO:0060012 synaptic transmission, glycinergic
GO:0060013 righting reflex
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109738
View Gene Order
ENSBTAG00000021764
Not yet available
Pathways
NETPATH
REACTOME
REACT_198558
Ligand-gated ion channel transport pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q3E3 Q99JG9
UniProt Splice Variant
Entrez Gene 14658
UniGene Mm.275639 Mm.397892 Mm.467689
RefSeq NM_001281969 NM_010298
OMIM
CCDS CCDS17424
HPRD
IMGT
MGI ID MGI:95751
MGI Symbol Glrb
EMBL AC121908 AJ300577
GenPept CAC34522
RNA Seq Atlas 14658

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca