InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rapgef1

Summary

InnateDB Protein

IDBP-153843.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Rapgef1

Protein Name

Rap guanine nucleotide exchange factor (GEF) 1

Synonyms

4932418O06Rik; C3G; Grf2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099936

InnateDB Gene

IDBG-153837 (Rapgef1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0001568	blood vessel development
GO:0007264	small GTPase mediated signal transduction
GO:0009967	positive regulation of signal transduction
GO:0016337	single organismal cell-cell adhesion
GO:0043087	regulation of GTPase activity
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051898	negative regulation of protein kinase B signaling
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

MGI:104580

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR023578 Ras guanine nucleotide exchange factor, domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite