Version 5.4
Mus musculus Gene: Rapgef1
Summary
InnateDB Gene IDBG-153837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rapgef1
Gene Name Rap guanine nucleotide exchange factor (GEF) 1
Synonyms 4932418O06Rik; C3G; Grf2
Species Mus musculus
Ensembl Gene ENSMUSG00000039844
Encoded Proteins
IDBP-153839
Rap guanine nucleotide exchange factor (GEF) 1
IDBP-153841
Rap guanine nucleotide exchange factor (GEF) 1
IDBP-153843
Rap guanine nucleotide exchange factor (GEF) 1
IDBP-536327
Rap guanine nucleotide exchange factor (GEF) 1
IDBP-539395
Rap guanine nucleotide exchange factor (GEF) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107263:
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:29619720-29740978
Strand Forward strand
Band B
Transcripts
ENSMUST00000095087 ENSMUSP00000092703
ENSMUST00000091146 ENSMUSP00000088680
ENSMUST00000102872 ENSMUSP00000099936
ENSMUST00000147755 ENSMUSP00000121615
ENSMUST00000147488 ENSMUSP00000117631
ENSMUST00000137719
ENSMUST00000123953
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017034 Rap guanyl-nucleotide exchange factor activity
Biological Process
GO:0001568 blood vessel development
GO:0007264 small GTPase mediated signal transduction
GO:0009967 positive regulation of signal transduction
GO:0010976 positive regulation of neuron projection development
GO:0016337 single organismal cell-cell adhesion
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0038180 nerve growth factor signaling pathway
GO:0043087 regulation of GTPase activity
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051898 negative regulation of protein kinase B signaling
GO:0061028 establishment of endothelial barrier
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901888 regulation of cell junction assembly
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005769 early endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107263
View Gene Order
ENSBTAG00000020791
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05211
Renal cell carcinoma pathway
mmu04910
Insulin signaling pathway pathway
mmu04510
Focal adhesion pathway
mmu04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
NetPath_17
IL5 pathway
REACTOME
REACT_23787
Regulation of signaling by CBL pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_12076
Frs2-mediated activation pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_11061
Signalling by NGF pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_12005
Prolonged ERK activation events pathway
KEGG
hsa05211
Renal cell carcinoma pathway
hsa04910
Insulin signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04722
Neurotrophin signaling pathway pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
reelinpathway
Reelin signaling pathway
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
epopathway
EPO signaling pathway
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
pdgfrapathway
PDGFR-alpha signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
insulin_pathway
Insulin Pathway
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL Q8C5V7
UniProt Splice Variant
Entrez Gene 107746
UniGene Mm.298274
RefSeq XM_006497589 XM_006497590 NM_001039086 NM_001039087 NM_054050 XM_006497582 XM_006497583 XM_006497584 XM_006497585 XM_006497586 XM_006497588 XM_006497591 XM_006497592
OMIM
CCDS CCDS15854 CCDS38091 CCDS38092
HPRD
IMGT
MGI ID MGI:104580
MGI Symbol Rapgef1
EMBL AK077034
GenPept BAC36578
RNA Seq Atlas 107746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca