InnateDB Protein
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IDBP-153850.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Helt
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Protein Name
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Hey-like transcription factor (zebrafish)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000054823
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InnateDB Gene
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IDBG-153848 (Helt)
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Protein Structure
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Function |
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons. {ECO:0000269PubMed:14764602, ECO:0000269PubMed:15071116, ECO:0000269PubMed:16968817, ECO:0000269PubMed:17611227}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:14764602, ECO:0000269PubMed:16644143}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3040955
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InterPro |
IPR003650
Orange
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF07527
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TS99
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q8BRJ9
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UniProt Splice Variant |
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Entrez Gene |
234219
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UniGene |
Mm.145631
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RefSeq |
NP_776150
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MGI ID |
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MGI Symbol |
Helt
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OMIM |
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CCDS |
CCDS22290
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HPRD |
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IMGT |
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EMBL |
AB098077
AB120968
AK044070
BC103599
BC103600
BC103601
CH466554
DQ294234
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GenPept |
AAI03600
AAI03601
AAI03602
ABB96784
BAC31761
BAC77659
BAD11127
EDL35571
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