InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il12rb2

Summary

InnateDB Protein

IDBP-153876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il12rb2

Protein Name

interleukin 12 receptor, beta 2

Synonyms

A930027I18Rik; Ifnm; IL-12RB2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010605

InnateDB Gene

IDBG-153874 (Il12rb2)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3. {ECO:0000269PubMed:12370372}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in developing T-helper (TH) cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	5 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032609	interferon-gamma production
GO:0032729	positive regulation of interferon-gamma production
GO:0034097	response to cytokine