InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mstn

Summary

InnateDB Protein

IDBP-153905.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mstn

Protein Name

myostatin

Synonyms

Cmpt; Gdf8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027269

InnateDB Gene

IDBG-153903 (Mstn)

Protein Structure

UniProt Annotation

Function

Acts specifically as a negative regulator of skeletal muscle growth.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed specifically in developing and adult skeletal muscle. Weak expression in adipose tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042802	identical protein binding

Biological Process

GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0009408	response to heat
GO:0009629	response to gravity
GO:0014732	skeletal muscle atrophy
GO:0014741	negative regulation of muscle hypertrophy
GO:0014850	response to muscle activity
GO:0022602	ovulation cycle process
GO:0033574	response to testosterone
GO:0040007	growth
GO:0043403	skeletal muscle tissue regeneration
GO:0043627	response to estrogen
GO:0045471	response to ethanol
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048632	negative regulation of skeletal muscle tissue growth
GO:0051384	response to glucocorticoid
GO:0051602	response to electrical stimulus
GO:0071549	cellular response to dexamethasone stimulus