Version 5.4
Mus musculus Gene: Mstn
Summary
InnateDB Gene IDBG-153903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mstn
Gene Name myostatin
Synonyms Cmpt; Gdf8
Species Mus musculus
Ensembl Gene ENSMUSG00000026100
Encoded Proteins
IDBP-153905
myostatin
IDBP-787625
myostatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138379:
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:53061640-53068079
Strand Forward strand
Band C1.1
Transcripts
ENSMUST00000027269 ENSMUSP00000027269
ENSMUST00000191197 ENSMUSP00000140249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042802 identical protein binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0009408 response to heat
GO:0009629 response to gravity
GO:0014732 skeletal muscle atrophy
GO:0014741 negative regulation of muscle hypertrophy
GO:0014850 response to muscle activity
GO:0022602 ovulation cycle process
GO:0033574 response to testosterone
GO:0040007 growth
GO:0043403 skeletal muscle tissue regeneration
GO:0043627 response to estrogen
GO:0045471 response to ethanol
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048632 negative regulation of skeletal muscle tissue growth
GO:0051384 response to glucocorticoid
GO:0051602 response to electrical stimulus
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138379
View Gene Order
ENSBTAG00000011808
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3514
RefSeq NM_010834
OMIM
CCDS CCDS14950
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca