InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubash3b

Summary

InnateDB Protein

IDBP-153911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubash3b

Protein Name

ubiquitin associated and SH3 domain containing, B

Synonyms

2810457I06Rik; BB125008; p70; TULA-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043865

InnateDB Gene

IDBG-153909 (Ubash3b)

Protein Structure

UniProt Annotation

Function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269PubMed:14738763, ECO:0000269PubMed:17679096, ECO:0000269PubMed:19733910, ECO:0000269PubMed:20585042}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in splenic T-cells and B-cells, total spleen, skeletal muscle, heart, lung, kidney, thymus, brain and liver (at protein level). Highly expressed in brain. Detected in heart, spleen, lung, liver, kidney and testis. {ECO:0000269PubMed:12370296, ECO:0000269PubMed:14738763}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0051279	regulation of release of sequestered calcium ion into cytosol
GO:0090331	negative regulation of platelet aggregation

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1920078

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR001452 SH3 domain
IPR009060 UBA-like
IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase
IPR013078 Histidine phosphatase superfamily, clade-1
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR029033 Histidine phosphatase superfamily

PFAM

PF00627
PF00018
PF14604
PF00300

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00855
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt