Version 5.4
Mus musculus Gene: Ubash3b
Summary
InnateDB Gene IDBG-153909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubash3b
Gene Name ubiquitin associated and SH3 domain containing, B
Synonyms 2810457I06Rik; BB125008; p70; TULA-2
Species Mus musculus
Ensembl Gene ENSMUSG00000032020
Encoded Proteins
IDBP-153911
ubiquitin associated and SH3 domain containing, B
IDBP-541461
ubiquitin associated and SH3 domain containing, B
IDBP-532470
ubiquitin associated and SH3 domain containing, B
IDBP-741908
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154127:
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:41011098-41161697
Strand Reverse strand
Band A5.1
Transcripts
ENSMUST00000044155 ENSMUSP00000043865
ENSMUST00000151485 ENSMUSP00000116038
ENSMUST00000124819
ENSMUST00000136530 ENSMUSP00000114176
ENSMUST00000129906 ENSMUSP00000134923
ENSMUST00000132996
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0090331 negative regulation of platelet aggregation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154127
View Gene Order
ENSBTAG00000000842
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.133615 Mm.392672 Mm.395432 Mm.421662 Mm.454936 Mm.486459
RefSeq NM_176860 XM_006510632 XM_006510634 XM_006510635 XM_006510636 XM_006510637
OMIM
CCDS CCDS23085
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca