InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccdc109a

Summary

InnateDB Protein

IDBP-153945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccdc109a

Protein Name

coiled-coil domain containing 109A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020312

InnateDB Gene

IDBG-153943 (Ccdc109a)

Protein Structure

UniProt Annotation

Function

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. {ECO:0000269PubMed:21685886, ECO:0000269PubMed:23900286}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000269PubMed:23900286}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, heart, kidney, liver, brain, lung, white fat and spleen. {ECO:0000269PubMed:21685888, ECO:0000269PubMed:23409044, ECO:0000269PubMed:23900286}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015292	uniporter activity
GO:0042802	identical protein binding

Biological Process

GO:0006851	mitochondrial calcium ion transport
GO:0019722	calcium-mediated signaling
GO:0032024	positive regulation of insulin secretion
GO:0035786	protein complex oligomerization
GO:0036444	calcium ion import into mitochondrion
GO:0042593	glucose homeostasis
GO:0051560	mitochondrial calcium ion homeostasis
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0031305	integral component of mitochondrial inner membrane
GO:0034704	calcium channel complex
GO:1990246	uniplex complex