InnateDB Protein
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IDBP-153947.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ccdc109a
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Protein Name
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coiled-coil domain containing 109A
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000009791
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InnateDB Gene
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IDBG-153943 (Ccdc109a)
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Protein Structure
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Function |
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. {ECO:0000269PubMed:21685886, ECO:0000269PubMed:23900286}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000269PubMed:23900286}.
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Disease Associations |
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Tissue Specificity |
Expressed in skeletal muscle, heart, kidney, liver, brain, lung, white fat and spleen. {ECO:0000269PubMed:21685888, ECO:0000269PubMed:23409044, ECO:0000269PubMed:23900286}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3026965
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InterPro |
IPR006769
Coiled-coil domain containing protein 109, C-terminal
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PFAM |
PF04678
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UMR5
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PhosphoSite |
PhosphoSite-Q3UMR5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
215999
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UniGene |
Mm.397150
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RefSeq |
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MGI ID |
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MGI Symbol |
Mcu
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC022699
AC155940
AK144727
AK161322
BC139254
BC139257
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GenPept |
AAI39255
AAI39258
BAE26033
BAE36322
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