InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sorl1

Summary

InnateDB Protein

IDBP-154028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sorl1

Protein Name

sortilin-related receptor, LDLR class A repeats-containing

Synonyms

2900010L19Rik; AI596264; AW261561; gp250; LR11; mSorLA; SorLA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058613

InnateDB Gene

IDBG-154026 (Sorl1)

Protein Structure

UniProt Annotation

Function

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems. Involved in APP trafficking to and from the Golgi apparatus (By similarity). It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta (By similarity). Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. {ECO:0000250, ECO:0000269PubMed:14764453}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}. Endosome {ECO:0000250}. Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding
GO:0030306	ADP-ribosylation factor binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0006605	protein targeting
GO:0006622	protein targeting to lysosome
GO:0006869	lipid transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006897	endocytosis
GO:0008203	cholesterol metabolic process
GO:0008283	cell proliferation
GO:0014910	regulation of smooth muscle cell migration
GO:0016477	cell migration
GO:0032091	negative regulation of protein binding
GO:0032460	negative regulation of protein oligomerization
GO:0043407	negative regulation of MAP kinase activity
GO:0045053	protein retention in Golgi apparatus
GO:0045732	positive regulation of protein catabolic process
GO:0050768	negative regulation of neurogenesis
GO:0051604	protein maturation
GO:0070863	positive regulation of protein exit from endoplasmic reticulum
GO:1901215	negative regulation of neuron death
GO:1902430	negative regulation of beta-amyloid formation
GO:1902771	positive regulation of choline O-acetyltransferase activity
GO:1902948	negative regulation of tau-protein kinase activity
GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955	positive regulation of early endosome to recycling endosome transport
GO:1902960	negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966	positive regulation of protein localization to early endosome
GO:1902997	negative regulation of neurofibrillary tangle assembly
GO:2001137	positive regulation of endocytic recycling

Cellular Component

GO:0005615	extracellular space
GO:0005641	nuclear envelope lumen
GO:0005768	endosome
GO:0005769	early endosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031985	Golgi cisterna
GO:0034362	low-density lipoprotein particle
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome