Version 5.4
Mus musculus Gene: Sorl1
Summary
InnateDB Gene IDBG-154026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sorl1
Gene Name sortilin-related receptor, LDLR class A repeats-containing
Synonyms 2900010L19Rik; AI596264; AW261561; gp250; LR11; mSorLA; SorLA
Species Mus musculus
Ensembl Gene ENSMUSG00000049313
Encoded Proteins
IDBP-154028
sortilin-related receptor, LDLR class A repeats-containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137642:
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer\'s Disease.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:41964720-42124297
Strand Reverse strand
Band A5.1
Transcripts
ENSMUST00000060989 ENSMUSP00000058613
ENSMUST00000134560
ENSMUST00000148800
ENSMUST00000139133
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
GO:0030169 low-density lipoprotein particle binding
GO:0030306 ADP-ribosylation factor binding
Biological Process
GO:0000042 protein targeting to Golgi
GO:0006605 protein targeting
GO:0006622 protein targeting to lysosome
GO:0006869 lipid transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0008203 cholesterol metabolic process
GO:0008283 cell proliferation
GO:0014910 regulation of smooth muscle cell migration
GO:0016477 cell migration
GO:0032091 negative regulation of protein binding
GO:0032460 negative regulation of protein oligomerization
GO:0043407 negative regulation of MAP kinase activity
GO:0045053 protein retention in Golgi apparatus
GO:0045732 positive regulation of protein catabolic process
GO:0050768 negative regulation of neurogenesis
GO:0051604 protein maturation
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:1901215 negative regulation of neuron death
GO:1902430 negative regulation of beta-amyloid formation
GO:1902771 positive regulation of choline O-acetyltransferase activity
GO:1902948 negative regulation of tau-protein kinase activity
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 positive regulation of early endosome to recycling endosome transport
GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1902997 negative regulation of neurofibrillary tangle assembly
GO:2001137 positive regulation of endocytic recycling
Cellular Component
GO:0005615 extracellular space
GO:0005641 nuclear envelope lumen
GO:0005768 endosome
GO:0005769 early endosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031985 Golgi cisterna
GO:0034362 low-density lipoprotein particle
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137642
View Gene Order
ENSBTAG00000014611
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.121920
RefSeq NM_011436
OMIM
CCDS CCDS40594
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca