InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ambp

Summary

InnateDB Protein

IDBP-154076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ambp

Protein Name

alpha 1 microglobulin/bikunin

Synonyms

AI194774; ASPI; HI-30; Intin4; Itil; UTI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030041

InnateDB Gene

IDBG-154074 (Ambp)

Protein Structure

UniProt Annotation

Function

Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity). {ECO:0000250}.Trypstatin is a trypsin inhibitor. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha- trypsin inhibitor is present in plasma and urine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0019862	IgA binding
GO:0020037	heme binding
GO:0036094	small molecule binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0010951	negative regulation of endopeptidase activity
GO:0018298	protein-chromophore linkage
GO:0030163	protein catabolic process
GO:0051604	protein maturation

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:88002

InterPro

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR002345 Lipocalin
IPR002968 Alpha-1-microglobulin
IPR002972 Prostaglandin D synthase
IPR011038 Calycin-like

PFAM

PF00061
PF08212
PF00014

PRINTS

PR00759
PR00179
PR01215
PR01254

PIRSF

SMART

SM00131

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt