Version 5.4
Mus musculus Gene: Ambp
Summary
InnateDB Gene IDBG-154074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ambp
Gene Name alpha 1 microglobulin/bikunin
Synonyms AI194774; ASPI; HI-30; Intin4; Itil; UTI
Species Mus musculus
Ensembl Gene ENSMUSG00000028356
Encoded Proteins
IDBP-154076
alpha 1 microglobulin/bikunin
IDBP-538329
alpha 1 microglobulin/bikunin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106927:
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:63143275-63154799
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000030041 ENSMUSP00000030041
ENSMUST00000142901 ENSMUSP00000118965
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0019862 IgA binding
GO:0020037 heme binding
GO:0036094 small molecule binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0018298 protein-chromophore linkage
GO:0030163 protein catabolic process
GO:0051604 protein maturation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106927
View Gene Order
ENSBTAG00000015676
Not yet available
Pathways
NETPATH
REACTOME
REACT_196575
Scavenging of heme from plasma pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I7HIQ9
UniProt Splice Variant
Entrez Gene 11699
UniGene Mm.474541
RefSeq NM_007443
OMIM
CCDS CCDS18248
HPRD
IMGT
MGI ID MGI:88002
MGI Symbol Ambp
EMBL AL691496
GenPept
RNA Seq Atlas 11699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca