Version 5.4
Mus musculus Protein: Mlf1ip
Summary
InnateDB Protein IDBP-154091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mlf1ip
Protein Name myeloid leukemia factor 1 interacting protein
Synonyms 1700029A22Rik; Mlf1ip;
Species Mus musculus
Ensembl Protein ENSMUSP00000034045
InnateDB Gene IDBG-154089 (Mlf1ip)
Protein Structure
UniProt Annotation
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Testis, spleen, heart, kidney, liver, lung, brain and CFU-E erythroid precursor cells. {ECO:0000269PubMed:15116101}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043009 chordate embryonic development
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
Protein Structure and Domains
PDB ID MGI:1919126
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C4M7
PhosphoSite PhosphoSite-Q8C4M7
TrEMBL
UniProt Splice Variant
Entrez Gene 71876
UniGene Mm.22108
RefSeq NP_082249
MGI ID
MGI Symbol Cenpu
OMIM
CCDS CCDS22292
HPRD
IMGT
EMBL AK006479 AK050386 AK081703 AY366362
GenPept AAR13082 BAB24609 BAC34227 BAC38300

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca