InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Whsc1

Summary

InnateDB Protein

IDBP-154159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Whsc1

Protein Name

Wolf-Hirschhorn syndrome candidate 1 (human)

Synonyms

5830445G22Rik; 9430010A17Rik; AW555663; C130020C13Rik; D030027O06Rik; D930023B08Rik; mKIAA1090; MMSET; NSD2; Whsc1l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058940

InnateDB Gene

IDBG-154157 (Whsc1)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. {ECO:0000269PubMed:18172012}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}. Chromosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed preferentially in rapidly growing embryonic tissues. {ECO:0000269PubMed:9618163}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003149	membranous septum morphogenesis
GO:0003289	atrial septum primum morphogenesis
GO:0003290	atrial septum secundum morphogenesis
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0034968	histone lysine methylation
GO:0060348	bone development

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:1276574

InterPro

IPR000313 PWWP domain
IPR001214 SET domain
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003616 Post-SET domain
IPR006560 AWS
IPR009071 High mobility group box domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM