Version 5.4
Mus musculus Gene: Whsc1
Summary
InnateDB Gene IDBG-154157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Whsc1
Gene Name Wolf-Hirschhorn syndrome candidate 1 (human)
Synonyms 5830445G22Rik; 9430010A17Rik; AW555663; C130020C13Rik; D030027O06Rik; D930023B08Rik; mKIAA1090; MMSET; NSD2; Whsc1l
Species Mus musculus
Ensembl Gene ENSMUSG00000057406
Encoded Proteins
IDBP-154159
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-154161
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-154163
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-251840
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-251842
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-542500
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-539573
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-533759
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-535972
Wolf-Hirschhorn syndrome candidate 1 (human)
IDBP-541813
Wolf-Hirschhorn syndrome candidate 1 (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109685:
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:33820725-33897975
Strand Forward strand
Band B2
Transcripts
ENSMUST00000058096 ENSMUSP00000058940
ENSMUST00000066854 ENSMUSP00000067205
ENSMUST00000075812 ENSMUSP00000075210
ENSMUST00000114399 ENSMUSP00000110041
ENSMUST00000114397 ENSMUSP00000110039
ENSMUST00000155880 ENSMUSP00000121805
ENSMUST00000139845 ENSMUSP00000123460
ENSMUST00000137191 ENSMUSP00000122310
ENSMUST00000141416 ENSMUSP00000117233
ENSMUST00000142080 ENSMUSP00000115251
ENSMUST00000133870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0003149 membranous septum morphogenesis
GO:0003289 atrial septum primum morphogenesis
GO:0003290 atrial septum secundum morphogenesis
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0034968 histone lysine methylation
GO:0060348 bone development
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109685
View Gene Order
ENSBTAG00000007986
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z229 D3Z3E4
UniProt Splice Variant
Entrez Gene 107823
UniGene Mm.19892 Mm.406909 Mm.408639 Mm.450994 Mm.490310
RefSeq NM_001081102 NM_001177884 NM_175231 XM_006503658 XM_006503659 XM_006503660 XM_006503661 XM_006503662 XM_006503663
OMIM
CCDS CCDS51467 CCDS51468
HPRD
IMGT
MGI ID MGI:1276574
MGI Symbol Whsc1
EMBL AC162898 AC163329
GenPept
RNA Seq Atlas 107823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca