InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xpo1

Summary

InnateDB Protein

IDBP-154347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xpo1

Protein Name

exportin 1, CRM1 homolog (yeast)

Synonyms

AA420417; Crm1; Exp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020538

InnateDB Gene

IDBG-154345 (Xpo1)

Protein Structure

UniProt Annotation

Function

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	137 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0008565	protein transporter activity
GO:0019904	protein domain specific binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006611	protein export from nucleus
GO:0006886	intracellular protein transport
GO:0010824	regulation of centrosome duplication
GO:0034504	protein localization to nucleus
GO:0042176	regulation of protein catabolic process
GO:0042493	response to drug
GO:0046825	regulation of protein export from nucleus
GO:0051028	mRNA transport

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005642	annulate lamellae
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0030529	ribonucleoprotein complex