Version 5.4
Mus musculus Protein: Nat8l
Summary
InnateDB Protein IDBP-154704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nat8l
Protein Name N-acetyltransferase 8-like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000059313
InnateDB Gene IDBG-154702 (Nat8l)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. {ECO:0000269PubMed:19014384, ECO:0000269PubMed:19807691, ECO:0000269PubMed:20385109, ECO:0000269PubMed:20643647}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in brain, kidney, liver and spleen. In brain, present in neurons but not in astrocytes (at protein level). Expressed in brain, thymus and spleen. {ECO:0000269PubMed:17626222, ECO:0000269PubMed:19807691, ECO:0000269PubMed:20385109}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008080 N-acetyltransferase activity
GO:0017188 aspartate N-acetyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID MGI:2447776
InterPro IPR000182 GNAT domain
IPR016181 Acyl-CoA N-acyltransferase
PFAM PF00583
PF13302
PF13508
PF13673
PF13718
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UGX3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 269642
UniGene Mm.274610
RefSeq NP_001001985
MGI ID
MGI Symbol Nat8l
OMIM
CCDS CCDS19210
HPRD
IMGT
EMBL AK147307 AK147594 AK147703 BC034068 BC075616 DQ174094
GenPept AAH34068 AAH75616 ABA54615 BAE27836 BAE28014 BAE28084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca