Version 5.4
Mus musculus Gene: Nat8l
Summary
InnateDB Gene IDBG-154702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nat8l
Gene Name N-acetyltransferase 8-like
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000048142
Encoded Proteins
IDBP-154704
N-acetyltransferase 8-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185818:
This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:33995984-34005916
Strand Forward strand
Band B2
Transcripts
ENSMUST00000056355 ENSMUSP00000059313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008080 N-acetyltransferase activity
GO:0017188 aspartate N-acetyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185818
View Gene Order
ENSBTAG00000031364
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00250
Alanine, aspartate and glutamate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q3UGX3
TrEMBL
UniProt Splice Variant
Entrez Gene 269642
UniGene Mm.274610
RefSeq NM_001001985
OMIM
CCDS CCDS19210
HPRD
IMGT
MGI ID MGI:2447776
MGI Symbol Nat8l
EMBL AK147307 AK147594 AK147703 BC034068 BC075616 DQ174094
GenPept AAH34068 AAH75616 ABA54615 BAE27836 BAE28014 BAE28084
RNA Seq Atlas 269642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca