InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Akna

Summary

InnateDB Protein

IDBP-154785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Akna

Protein Name

AT-hook transcription factor

Synonyms

AI597013; mKIAA1968;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041614

InnateDB Gene

IDBG-154783 (Akna)

Protein Structure

UniProt Annotation

Function

Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003674	molecular_function
GO:0003677	DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter