InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plaur

Summary

InnateDB Protein

IDBP-154829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plaur

Protein Name

plasminogen activator, urokinase receptor

Synonyms

Cd87; u-PAR; uPAR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002284

InnateDB Gene

IDBG-154827 (Plaur)

Protein Structure

UniProt Annotation

Function

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

Subcellular Localization

Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

Expressed in angiogenic endothelial cells (at protein level). {ECO:0000269PubMed:19667118}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0045087

innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome