InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgdig

Summary

InnateDB Protein

IDBP-154873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgdig

Protein Name

Rho GDP dissociation inhibitor (GDI) gamma

Synonyms

Gdi5; Rho-GDI-3; Rho-GDI2; RIP2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025019

InnateDB Gene

IDBG-154871 (Arhgdig)

Protein Structure

UniProt Annotation

Function

Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected only in brain, lung, kidney and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005083	small GTPase regulator activity
GO:0005092	GDP-dissociation inhibitor activity
GO:0005094	Rho GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding