InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spna2

Summary

InnateDB Protein

IDBP-154898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spna2

Protein Name

spectrin alpha 2

Synonyms

2610027H02Rik; Spna-2; Spna2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097797

InnateDB Gene

IDBG-154896 (Spna2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	102 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030507	spectrin binding
GO:0046982	protein heterodimerization activity

Biological Process

Cellular Component

GO:0005916	fascia adherens
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030018	Z disc
GO:0030863	cortical cytoskeleton
GO:0032437	cuticular plate
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98386

InterPro

IPR001452 SH3 domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin

PFAM