InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spna2

Summary

InnateDB Protein

IDBP-154900.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spna2

Protein Name

spectrin alpha 2

Synonyms

2610027H02Rik; Spna-2; Spna2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092697

InnateDB Gene

IDBG-154896 (Spna2)

Protein Structure

UniProt Annotation

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	102 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030507	spectrin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0051693

actin filament capping

Cellular Component

GO:0005916	fascia adherens
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030018	Z disc
GO:0030863	cortical cytoskeleton
GO:0032437	cuticular plate
GO:0033270	paranode region of axon

Protein Structure and Domains

PDB ID

MGI:98386

InterPro

IPR001452 SH3 domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin

PFAM