InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspd1

Summary

InnateDB Protein

IDBP-155164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspd1

Protein Name

heat shock protein 1 (chaperonin)

Synonyms

60kDa; Hsp60;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027123

InnateDB Gene

IDBG-155162 (Hspd1)

Protein Structure

UniProt Annotation

Function

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0002039	p53 binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0002368	B cell cytokine production
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002842	positive regulation of T cell mediated immune response to tumor cell
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986	response to unfolded protein
GO:0032727	positive regulation of interferon-alpha production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0042026	protein refolding
GO:0042100	B cell proliferation
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0043032	positive regulation of macrophage activation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048291	isotype switching to IgG isotypes
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016020	membrane
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135	coated vesicle
GO:0030141	secretory granule
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0046696	lipopolysaccharide receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96242

InterPro

IPR001844 Chaperonin Cpn60
IPR002423 Chaperonin Cpn60/TCP-1
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
IPR027409 GroEL-like apical domain

PFAM

PF00118

PRINTS

PR00298
PR00304

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P63038