InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hspd1

Summary

InnateDB Gene

IDBG-155162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspd1

Gene Name

heat shock protein 1 (chaperonin)

Synonyms

60kDa; Hsp60

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025980

Encoded Proteins

IDBP-155164

heat shock protein 1 (chaperonin)

IDBP-536896

heat shock protein 1 (chaperonin)

IDBP-532491

heat shock protein 1 (chaperonin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21145789

Hspd1 plays a dual role as an immune modulator and a biomarker, and is a target to modulate immunity for therapeutic purposes, and to monitor the immune response in health and disease.

PMID 21775438

Hspd1 and Tlr4 mediate myocardial ischemia-activated innate immune signalling, which plays an important role in mediating apoptosis and inflammation during ischemia/reperfusion (I/R).

InnateDB Annotation from Orthologs

Summary

PMID 18575269

[Homo sapiens] HSPD1 is part of the heat shock family of proteins that have many roles in inflammation and regulation of the immune system.

PMID 21145789

[Homo sapiens] HSPD1 plays a dual role as an immune modulator and a biomarker, and is a target to modulate immunity for therapeutic purposes, and to monitor the immune response in health and disease.

PMID 21775438

[Homo sapiens] HSPD1 and TLR4 mediate myocardial ischemia-activated innate immune signalling, which plays an important role in mediating apoptosis and inflammation during ischemia/reperfusion (I/R). (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144381:
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:55077835-55088243

Strand

Reverse strand

Band

C1.2

Transcripts

ENSMUST00000027123	ENSMUSP00000027123
ENSMUST00000127861	ENSMUSP00000119336
ENSMUST00000144077	ENSMUSP00000122947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0002039	p53 binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0002368	B cell cytokine production
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002842	positive regulation of T cell mediated immune response to tumor cell
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986	response to unfolded protein
GO:0032727	positive regulation of interferon-alpha production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0042026	protein refolding
GO:0042100	B cell proliferation
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0043032	positive regulation of macrophage activation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048291	isotype switching to IgG isotypes
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0016020	membrane
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135	coated vesicle
GO:0030141	secretory granule
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0046696	lipopolysaccharide receptor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000144381

View Gene Order

ENSBTAG00000012586

Not yet available

Pathways

NETPATH

REACTOME

REACT_247926

Metabolism of proteins pathway

REACT_199101

Mitochondrial protein import pathway

KEGG

mmu04940

Type I diabetes mellitus pathway

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa04940

Type I diabetes mellitus pathway

hsa03018

RNA degradation pathway

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

toll_endogenous_pathway

Endogenous TLR signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.1777 Mm.428249 Mm.473987 Mm.486509

RefSeq

NM_010477 XM_006495706 XM_006543431

OMIM

CCDS

CCDS35569

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas