Version 5.4
Mus musculus Protein: Tbata
Summary
InnateDB Protein IDBP-155200.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbata
Protein Name thymus, brain and testes associated
Synonyms 1700021K02Rik; AI428928; Spatial; Titest;
Species Mus musculus
Ensembl Protein ENSMUSP00000036422
InnateDB Gene IDBG-155198 (Tbata)
Protein Structure
UniProt Annotation
Function Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway. {ECO:0000269PubMed:17196196, ECO:0000269PubMed:20937703}.
Subcellular Localization Isoform 1: Cytoplasm, cytosol {ECO:0000269PubMed:17196196}. Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail. {ECO:0000269PubMed:17196196}.Isoform 2: Cytoplasm, cytosol {ECO:0000269PubMed:17196196}. Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail. {ECO:0000269PubMed:17196196}.Isoform 6: Nucleus {ECO:0000269PubMed:11196687}.Isoform 7: Nucleus {ECO:0000269PubMed:11196687}.
Disease Associations
Tissue Specificity Expressed in the subcapsular region of the thymus and lymph node (at protein level). Highly expressed in thymic cortical stromal cells and testis. Lower levels found in brain cortex, hippocampus, kidney, cerebellum, skeletal muscle, epididymis and ovary. No expression detected in other lymphoid organs including bone marrow and spleen. Isoform 1 and isoform 2 are expressed predominantly in testis. Isoform 3, isoform 4 and isoform 5 are expressed predominantly in thymus although isoform 3 is also expressed in testis. In the CNS, highly expressed in restricted areas, the cerebellum and hippocampus. {ECO:0000269PubMed:12711538}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0048515 spermatid differentiation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1923820
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TSD4
PhosphoSite PhosphoSite-Q7TSD4
TrEMBL
UniProt Splice Variant
Entrez Gene 65971
UniGene Mm.30227
RefSeq NP_001017433
MGI ID
MGI Symbol Tbata
OMIM
CCDS CCDS23873
HPRD
IMGT
EMBL AF257502 AF257503 AF521591 AF521592 AK038284 AY243457 AY243458 AY243459 EU622858
GenPept AAG37103 AAG37104 AAP41210 AAP41211 AAP41212 AAP50907 AAP50908 ACD01420 BAC29958

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca